About

Orna Resnekov Deputy Director Email: oresnekovmolsci.org Tel: 510-981-8711 Download NIH Biosketch (PDF format)

My research focuses on how cells sense their environment and transmit information to create an appropriate cellular response. I am currently concentrating on understanding information flow in yeast cells exposed to mating pheromone. The pathway is prototypic, well understood and involves a kinase cascade. Using mass spectrometric methods, biochemistry and genetics I study pheromone-induced phosphorylation of functionally relevant sites on pheromone pathway proteins. In this work I collaborate closely with Robert Maxwell (PNNL), David Pincus (MSI), Chris Ryan (MSI), and Richard Smith (PNNL). Recently we comprehensively catalogued pathway phosphorylation sites and characterized the dynamics of certain pathway phosphorylation events. We have genetically tested a subset of the newly identified phosphorylation sites and in collaboration with Annie Tsong (MSI) we are exploring whether all the residues that we identified as being phosphorylated are conserved during evolution. I previously worked on the Gram-positive microorganism, Bacillus subtilis where I acquired extensive experience studying signal transduction using genetics, protein purification and the analysis and use of GFP derivatives.

I am also the project manager of the Center for Quantitative Genome Function and the Deputy Director of MSI.

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